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Dog Vaccines 101: The Science of Safety

December 16, 2025 Jocelyn Michaud, CVT
Dog Vaccines 101: The Science of Safety

Vaccines are one of the most powerful tools in keeping your dog safe and healthy.  

“Vaccines train your pet’s immune system to fight off contagious and potentially serious diseases, which helps protect both your dog and the pets in your community,” says Dr. Clay Hellner of Pet Paradise + NewDay Veterinary Care. Understanding the science behind vaccines can help you see why staying up to date on vaccinations is one of the best ways to safeguard your dog’s health. 

How Vaccines Help the Immune System Learn 

Vaccines work by teaching the immune system how to recognize and respond to specific diseases. According to Cornell University’s College of Veterinary Medicine, a vaccine exposes the body to a harmless version of a pathogen (like a virus or bacterium, for example). To get technical, the vaccine is composed of an antigen (a small piece of a pathogen) and an adjuvant (a “whistleblower”) which tells the immune system to react and be ready for future encounters.  

In short, a vaccine gives the immune system a “practice run” against a disease before it encounters the real thing. When a vaccinated dog meets the real disease later, their immune system knows exactly what to do: protect against infection. This is called “immunological memory,” and it turns a simple shot into a big layer of protection. 

All this immune system training can take up to a couple of weeks. And even after the first dose, your dog’s body may not have enough protective cells built up yet. That’s why booster vaccines are so important: they give the immune system another chance to strengthen its response and build the level of protection your dog needs to fight off disease. 

Vaccines: Your Dog’s Safety Net 

One of the biggest misconceptions about vaccines is that they stop disease entirely. While some vaccines can prevent infection, others are designed to reduce severity and the risk of transmission. Respiratory illnesses like canine influenza (“flu”) or kennel cough (Bordetella) are good examples. 

Even if a vaccinated dog is exposed to a disease like the canine flu, their symptoms are milder and shorter in duration compared to an unvaccinated dog. As Dr. Hellner explains, “A vaccine is like a safety net. It helps prevent the worst outcomes and limits the spread of illness to other pets.” 

What Happens If You Don’t Vaccinate Your Dog? 

Choosing not to vaccinate leaves your dog vulnerable to many preventable illnesses, and some of these diseases can become severe very quickly. Dogs without vaccine protection are more likely to develop complications, require emergency care, or face significantly longer recovery times when they get sick. 

Many contagious diseases spread before symptoms are obvious, which means an unvaccinated dog can unknowingly put other pets at risk. Diseases like parvovirus, distemper, rabies, kennel cough, canine flu, and leptospirosis are highly contagious, which is why vaccination plays such an important role in your dog’s long-term health. 

Some diseases, like rabies and leptospirosis, are zoonotic, meaning humans can contract the disease from dogs. Staying up to date on vaccines helps protect both the pets and people in your community. 

Common Myths About Dog Vaccines 

Let’s clear up some of the most common vaccine myths so you can protect your dog with confidence. 

Myth: “Vaccines are risky and commonly cause adverse reactions.” 

Fact: Vaccine reactions are considered uncommon. According to a recent study, fewer than 0.2% of dogs experience an adverse reaction to vaccines. The most common vaccine reactions include swelling at the injection site, muscle soreness, swollen lymph nodes, or mild fever for a couple days. Those symptoms are a sign that the vaccine is doing its job and training the immune system to fight the real disease. 

Myth: “My dog is small, so they should get a smaller vaccine dose.” 

Fact: Vaccines are designed to stimulate the immune system. A smaller dose wouldn’t create the protection your pet needs. According to the American Animal Hospital Association (AAHA), vaccine doses do not change based on a dog’s size, and there is no evidence that lowering the volume of a vaccine will prevent an adverse event. 

Myth: “Vaccines don’t completely prevent every infection, so there’s no point!” 

Fact: Reducing the severity of symptoms is a major success. A mild cough instead of pneumonia makes a meaningful difference for a dog’s health and safety. 

Myth: “My dog is indoors most of the time, so vaccines aren’t necessary.” 

Fact: Even indoor-only dogs can be exposed to diseases. Some viruses can even travel on shoes or clothing without any direct contact with another animal. Additionally, pets can be exposed through routine veterinary visits, grooming appointments, boarding stays, or contact with visiting pets. 

Myth: “My dog’s vaccines only protect my dog.” 

Fact: Vaccines help protect the entire pet community. When a dog is vaccinated, it reduces how much disease can circulate in places where pets spend time together. With more dogs protected, contagious illnesses have fewer chances to spread. In the case of zoonotic diseases like leptospirosis or rabies, vaccines protect both pets and people alike. 

A Smart Step Toward a Healthier Future 

Vaccines aren’t just part of a to-do list. They’re one of the best ways to help dogs stay healthy and avoid preventable illnesses. As Dr. Hellner says, “Vaccination is one of the kindest things we can do for our pets. We’re helping their immune system prepare for risks they can’t see.” 

For more information about wellness and preventive care, explore our blog on vaccines for outgoing pets

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Meet Our Veterinary Authors

Our Veterinarians are at the center of everything we do at Pet Paradise + NewDay Veterinary Care. They not only inform our resort operations, vet clinics, science-backed dog training and the way we groom our dogs, but they also contribute to our articles for medical accuracy and insight.

Dr Clay Hellner DVM

Dr. Clay Hellner, Chief Veterinary Officer

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Dr. Karen O'Connor, Regional Veterinary Medical Director

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Dr. Steve Capron, Fellow of the Academy of Veterinary Dentistry

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